Cytosine methylation of CpG dinucleotides is an important epigenetic mark that regulates gene expression in humans. While methylation patterns in extant populations have been widely studied, few studies have attempted to analyze methylation in ancient DNA. Indeed, it was only recently shown that methyl groups can be preserved in ancient DNA. This PhD research used ancient DNA techniques to investigate a number of biogeographic scenarios in relation to the phylogeography of brown bears ( Ursus arctos ) in Europe (Chapter 2- 4) and across the Eurasian continent (Chapter 5) throughout the Late Pleistocene and
Jun 20, 2019 · June 20 (UPI) — Scientists have gained new insights into the history of Japan’s early residents by analyzing the Y chromosomes of modern Japanese men. The analysis allowed researchers to estimate the ancient human population living on Japan’s main island some 2,500 years ago.